Sperm morphology and cytogenetic studies in ageing C57BL/6 mice

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Abstract
A dose-response relationship was observed in the percentage of morphologically abnormal spermatozoa as a function of age for 2-, 6-, 12-, 18- and 25-mo.-old C57BL/6 male mice. Compared with values for younger mice, 25-mo-old mice had a significantly (P < 0.005) higher percentage of abnormal spermatozoa (23.9 .+-. 2.3%) and the percentages in mice aged 12 (12.9 .+-. 0.7%) and 18 (14.3 .+-. 1.3%) mo. were significantly (P < 0.05) different from those of 2-mo-old animals (10.5 .+-. 0.7%). Significant differences were not observed in the cytogenetic studies for 6-, 12-, 18- and 25-mo.-old mice, although 2-mo.-old mice had a lower frequency (P < 0.05) of chromosomal aberrations compared to 12- and 18-mo.-old animals.

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