Antiestrogenic properties of substituted benz[a]anthracene-3,9-diols
- 1 March 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (3) , 323-326
- https://doi.org/10.1021/jm00345a018
Abstract
The antiestrogenic potency of benz[a]anthracene-3,9-diol, as well as its 7- and 12-methyl derivatives, was evaluated by measuring the inhibition in the onset of estrus brought about by this compound in ovariectomized rats treated with 17.beta.-estradiol. At a dose of 0.5 mg the 7,12-dimethyl derivative caused a decrease in the percentage of rats in estrus from 78 to 44%. This decrease is identical with that caused by 0.05 mg of nafoxidine. [Applicability of this study to treatment of breast cancer by antiestrogens is discussed.].This publication has 7 references indexed in Scilit:
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