Degradation of Chondroitin 4-Sulfate by Rat Stomach Exoglycosidases, Sulfohydrolase and Hyaluronidase-Like Enzymes
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 21 (3) , 117-124
- https://doi.org/10.1159/000198552
Abstract
Rat stomach enzymes degrade chondroitin 4-sulfate (C4-S) by cooperative enzyme action yielding monosaccharides, SO42- and oligosaccharides. Evidence for this was obtained by analyzing the effects of adding inhibitors and rate-limiting enzyme to incubation mixtures. A size preference appears to exist, since oligosaccharides of .**GRAPHIC**. [average degree of polymerization] 4-10 [monosaccharide units/molecule] liberated by a gastric hyaluronidase-like enzyme is a poor substrate for desulfation by the gastric enzyme complex.This publication has 1 reference indexed in Scilit:
- Study on the Degradation of Glycosaminoglycans by Canine Liver Lysosomal EnzymesThe Journal of Biochemistry, 1978