The Thickness of the Glomerular Basement Membrane in Congenital Nephrotic Syndrome of the Finnish Type

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Abstract
EM examination was carried out on 10 glomeruli from 4 infants with congenital nephrotic syndrome of the Finnish type (CNF) and 5 glomeruli from 1 control. The thickness of the peripheral glomerular basement membrane (GBM) and lamina densa were measured. The width of the GBM was thinner in CNF than in the control but still within normal limits for the age and the width of the lamina densa was thinner in CNF than in the control. The basic defect in CNF may be a faulty synthesis of the lamina densa.

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