Pregnane X Receptor: Promiscuous regulator of detoxification pathways
- 1 January 2007
- journal article
- review article
- Published by Elsevier in The International Journal of Biochemistry & Cell Biology
- Vol. 39 (3) , 478-483
- https://doi.org/10.1016/j.biocel.2006.08.017
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- Expression of the Steroid and Xenobiotic Receptor and Its Possible Target Gene, Organic Anion Transporting Polypeptide-A, in Human Breast CarcinomaCancer Research, 2006
- Phosphorylation of the Retinoid X Receptor at the Omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificityCellular Signalling, 2005
- Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRα phosphorylationJournal of Clinical Investigation, 2005
- The Identification of Ligand Features Essential for PXR Activation by Pharmacophore ModelingJournal of Chemical Information and Modeling, 2005
- Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in miceHepatology, 2004
- Identification of Pregnane X Receptor Binding Sites in the Regulatory Regions of Genes Involved in Bile Acid HomeostasisJournal of Molecular Biology, 2004
- PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activatorsToxicology and Applied Pharmacology, 2004
- Transgenic Mouse Models of Human CYP3A4 Gene RegulationMolecular Pharmacology, 2003
- Nuclear Hormone Receptor Targeted Virtual ScreeningJournal of Medicinal Chemistry, 2003
- Humanized xenobiotic response in mice expressing nuclear receptor SXRNature, 2000