Cooling: a New Approach to Bladder Denervation

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Abstract
Cooling tissues to temperatures close to zero preferentially destroys nerve. In vivo intracavity cooling of the urinary bladder of rabbits to temperatures between 0 degrees and 5 degrees C produced partial denervation of intramural nerves, assessed by silver staining techniques. All other tissues appeared normal histologically. Detrusor muscle function, assessed in vivo by cystometry and in vitro pharmacologically, was unaffected by this procedure, but 11 out of 18 rabbits showed long-term large increases in conscious bladder capacity following cooling.

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