"Vascular" Purpura Caused by Oxytetracycline

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Abstract
To the Editor:— The following report briefly records a unique case of "vascular" purpura occurring as an allergic reaction to small doses of oxytetracycline. Hazards associated with the administration of the drug in the presence of intrinsic renal disease have been recognized. Two cases of thrombocytopenic purpura following the use of oxytetracycline have been reported previously. The patient was a 73-year-old white male who was admitted to our hospital because of empyema secondary to bronchopneumonia. He was treated with surgical drainage and chloramphenicol (Chloromycetin), 500 mg four times daily for four weeks. At the end of this time, the empyema completely resolved. Two weeks later, a low-grade fever recurred because of the exacerbation of a long-standing chronic pyelonephritis, and treatment with oxytetracycline, 500 mg four times daily, was started. On the third day, severe purpura developed. The blood count, platelet count, bone marrow smear, bleeding time, clotting time, and prothrombin

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