Capture of an early fusion-active conformation of HIV-1 gp41
- 1 April 1998
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 5 (4) , 276-279
- https://doi.org/10.1038/nsb0498-276
Abstract
Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.Keywords
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