Correlation of Multiple Sclerosis Measures Derived from T2-Weighted, T1-Weighted, Magnetization Transfer, and Diffusion Tensor MR Imaging

  • 1 September 2001
    • journal article
    • research article
    • Vol. 22  (8) , 1462-1467
Abstract
BACKGROUND AND PURPOSE: In multiple sclerosis (MS), the severity of tissue damage can vary from edema and inflammation to irreversible demyelination and axonal loss. Compared with conventional T2-weighted MR imaging, magnetization transfer (MT) and diffusion tensor (DT) MR imaging provide quantitative indices with increased specificity to the most destructive aspects of MS. To increase our understanding of the pathophysiologic processes of MS, we assessed the correlations between MT and DT MR imaging–derived metrics and the correlations between these quantities and measures derived from conventional MR in patients with MS.

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