In Vivo Electron Spin Resonance Assessment of Decay Constant of Nitroxyl Radical in Selenium-Deficient Rat.
Open Access
- 1 January 2000
- journal article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 23 (5) , 641-644
- https://doi.org/10.1248/bpb.23.641
Abstract
In vivo reducing capacity and cytosolic glutathione peroxidase (GSH-Px) activity in liver homogenate were evaluated in 6 weeks old Se-deficient and normal rats. GSH-Px was significantly lower in Se-deficient rats than in normal rats. In vivo reducing capacity in head and liver parts, estimated from in vivo signal decay of a nitroxyl spin probe using a low frequency (300 MHz) ESR spectrometer, was significantly decreased in Se-deficient rats, suggesting a decrease of antioxidant capacity in Se-deficient rats.Keywords
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