Contribution of CD8+T Cells to Gamma Interferon Production in Human Tuberculosis
Open Access
- 1 May 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (5) , 3497-3501
- https://doi.org/10.1128/iai.69.5.3497-3501.2001
Abstract
The proportions of peripheral blood mononuclear cells (PBMC), CD4+T cells, and CD8+T cells that produce gamma interferon (IFN-γ) in response toMycobacterium tuberculosiswere markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4+but not CD8+cells prior to stimulation of PBMC withM. tuberculosisabolished IFN-γ production. These results show that (i) IFN-γ production by CD8+and CD4+cells correlates with the clinical manifestations ofM. tuberculosisinfection and (ii) IFN-γ production by CD8+cells depends on CD4+cells.Keywords
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