SPECIFIC INHIBITION OF ALDOSTERONE RESPONSES TO ENDOGENOUS AND EXOGENOUS ANGIOTENSIN II BY SOMATOSTATIN

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Abstract
Aldosterone and renin responses to head-up tilt (60.degree. for 1 h) and angiotensin II infusions (2, 5 and 10 ng/kg per min) 1 h later were compared in 6 normal subjects during infusions of somatostatin (3 .mu.g/kg per min) or saline. The infusions were performed on separate days 2 wk apart. The increase in aldosterone due to exogenous angiotensin II and orthostasis was significantly attenuated by somatostatin. Neither the increase in plasma renin activity (PRA) nor the angiotensin II mediated suppression of PRA were affected by somatostatin. Somatostatin may suppress aldosterone release in response to angiotensin II in rat adrenal cells in culture. Somatostatin may regulate aldosterone secretion.