Convenient synthesis of 4-nitrotetralones by selective side-chain nitration of methyl-substituted acryloylbenzenes, followed by intramolecular Michael reaction
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 14,p. 1091-1092
- https://doi.org/10.1039/c39870001091
Abstract
Reaction of polymethyl-substituted acryloylbenzenes (1) with fuming nitric acid in acetic anhydride gave the products (2) derived from selective side-chain nitration at the ortho-position; the subsequent intramolecular Michael reaction leads to exclusive formation of 4-nitrotetralones (3).Keywords
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