Structure Elucidation Via Stereoselective Synthesis of the Acetate Center of 1-Azabicyclo[2.2.2]oct-3-yl α-Hydroxy- α-(1-iodo-1-propen-3-yl)-α-phenylacetate (IQNP). A High Affinity Muscarinic Imaging Agent for SPECT
- 15 November 1996
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 61 (23) , 8335-8337
- https://doi.org/10.1021/jo961033t
Abstract
No abstract availableThis publication has 8 references indexed in Scilit:
- Resolution and in Vitro and Initial in Vivo Evaluation of Isomers of Iodine-125-Labeled 1-Azabicyclo[2.2.2]oct-3-yl .alpha.-Hydroxy-.alpha.-(1-iodo-1-propen-3-yl)-.alpha.-phenylacetate: A High-Affinity Ligand for the Muscarinic ReceptorJournal of Medicinal Chemistry, 1995
- Characterization of in vivo brain muscarinic acetylcholine receptor subtype selectivity by competition studies against (
I]QNB Brain Research, 1995 - In vivo metabolic studies of thetrans-(R,R) isomer of radioiodinated IQNP: A new ligand with high affinity for the M1 muscarinic-cholinergic receptorEuropean Journal of Nuclear Medicine and Molecular Imaging, 1994
- Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(1-iodo-1-propen-3-yl)-.alpha.-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomographyJournal of Medicinal Chemistry, 1993
- (α-Alkylation of α-heterosubstituted carboxylic acids without racemizationTetrahedron, 1984
- Synthesis of enantiomerically enriched atrolactic acid and other α-hydroxy acidsTetrahedron Letters, 1981
- The central and peripheral activities of anti-acetylcholine drugs. Some concepts of practical relevanceJournal of Pharmacy and Pharmacology, 1973
- Absolute configuration of 3-quinuclidinyl benzilate and the behavioral effect in the dog of the optical isomersJournal of Medicinal Chemistry, 1972