RESISTANCE OF 129/J MICE TO SCHISTOSOMA MANSONI INFECTION
- 1 August 1986
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 64 (4) , 345-349
- https://doi.org/10.1038/icb.1986.36
Abstract
Mice of the strain 129/J bred at this Institute (WEHI 129/J) were exposed once or repeatedly to cercariae of Schistosoma mansoni and worm burdens determined. In keeping with reports of S. japonicum infection in these mice, a high level of resistance was recorded. Radio-labelled extracted antigens of S. mansoni adult worms were reacted with sera from exposed 129/J mice and infected BALB/c mice. Immunoprecipitated antigens preferentially recognized by antibodies in 129/J mice include proteins of Mr 99,000 and 21,000. Whether responses to these antigens are a cause or a consequence of resistance remains to be established.Keywords
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