THE STATE OF PROGESTERONE IN PLACENTAL TISSUE1

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Abstract
The yields of alpha, beta-unsaturated ketones obtained from human placental tissue by acetone extraction and by procedures involving alkaline digestion and ether extraction are of the same order of magnitude. The estimation is based on u.-v. spectroscopy. These findings militate against the view recently advanced that protein interacts with progesterone in placental tissue to form a stable complex from which the progesterone is not easily extracted by organic solvents. Apart from this consideration, our data do not argue for or against the existence of a progesterone-protein complex.

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