Tobramycin pharmacokinetics in morbidly obese patients
- 1 October 1979
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 26 (4) , 508-512
- https://doi.org/10.1002/cpt1979264508
Abstract
Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t½s of 0.285 and 2.1 hr. The volume of distribution (Varea) was determined to be 0.44 l/kg ideal body weight (IBW) and 0.20 l/kg total body weight (TBW). To normalize Varea to 0.26 l/kg, 58% of the patients’ adipose weight (TBW — IBW) must also be taken into account.This publication has 4 references indexed in Scilit:
- Amikacin Serum Concentrations: Prediction of Levels and Dosage GuidelinesAnnals of Internal Medicine, 1978
- A Controlled Investigation of the Pharmacokinetics of Gentamicin and Tobramycin in Obese SubjectsThe Journal of Infectious Diseases, 1978
- Gentamicin Serum Concentrations: Pharmacokinetic PredictionsAnnals of Internal Medicine, 1976
- Gentamicin Dosages for Renal InsufficiencyAnnals of Internal Medicine, 1971