A case report of cimetidine-induced clozapine toxicity.

  • 1 January 1991
    • journal article
    • case report
    • Vol. 52  (1) , 21-2
Abstract
Cimetidine may decrease concomitant medication clearance by inhibiting the oxidative system of cytochrome P-450. The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia.

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