Scale-Rich Metabolic Networks

25 April 2005

journal article
research article
Published by American Physical Society (APS) in Physical Review Letters

Vol. 94 (16) , 168101
https://doi.org/10.1103/physrevlett.94.168101

Abstract

Recent research in biology has clarified many features of the global organization of metabolic networks, including the biochemical mechanisms responsible for power laws in metabolite degrees. The primary aim of this Letter is to give the simplest possible biochemical explanations and minimal toy models based on a highly optimized tolerance perspective, which show where and why metabolic networks have power laws. A second aim is to further explain why scale-free explanations fail in this case to correctly describe metabolism.

Keywords

This publication has 9 references indexed in Scilit:

Bow ties, metabolism and disease
Trends in Biotechnology, 2004
The metabolic world of Escherichia coli is not small
Proceedings of the National Academy of Sciences, 2004
Network biology: understanding the cell's functional organization
Nature Reviews Genetics, 2004
The connectivity structure, giant strong component and centrality of metabolic networks
Bioinformatics, 2003
Evolution of Networks
Published by Oxford University Press (OUP) ,2003
Reverse Engineering of Biological Complexity
Science, 2002
Complexity and robustness
Proceedings of the National Academy of Sciences, 2002
Highly Optimized Tolerance: Robustness and Design in Complex Systems
Physical Review Letters, 2000
Fractals and Scaling in Finance
Published by Springer Nature ,1997