EFFECTS OF HEROIN ADDICTION ON THYROTROPHIN, THYROID HORMONES AND PROLACTIN SECRETION IN MEN

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Abstract
Pituitary-thyroid function in male heroin addicts and addicts after abstinence (ex-addicts) was studied and compared with that of healthy euthyroid men. In heroin addicts the increases in circulating total thyroxine [T4] and triiodothyronine [T3] levels were accompanied by an increase in the thyroid hormone uptake test. These changes may reflect a quantitative increase in T4 binding globulin. Reverse T3 concentrations in heroin addicts were normal. The thyrotropin-releasing hormone elicited a diminished thyrotropin response in heroin addicts which was significantly different from that in control subjects and ex-addicts. An elevation of serum prolactin was noted in heroin addicts, while ex-addicts had normal levels. Gradual recovery of pituitary-thyroid function occurred after heroin withdrawal.