Female age predicts embryonic implantation after ICSI: a case-controlled study

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Abstract
From 1 October 1991 until 31 December 1993, 1270 cycles for intracytoplasmic sperm injection were performed. Of these, 71 (5.6%) were carried out in women ≥40 years of age. The semen characteristics in couples≥40 years of age or P <0.001). The mean female age was 41.9 years (range 40–-47) and 31.8 years (range 23–39). The numbers of cumulus—oocyte complexes and metaphase-II oocytes were significantly lower in women ≤40 years of age (P < 0.001). The mean numbers of replaced embryos were respectively 2.3 (133/59) in women ≥40 years of age and 2.5 (160/63) in women <40 years of age. The delivery rate per retrieval and per transfer was significantly lower in women ≥40 years of age (P < 0.05). The delivery rates per retrieval and per transfer were respectively 7% (5/71) and 8.5% (5/59) in the older group of women versus22.5% (16/71) and 25.4% (16/63) in the younger group. Female age is the predictive factor for embryonic implanatation.

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