Novel Types of Bicyclonucleosides: Isoxazolidinofuranosylthymines
- 1 December 1994
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (10) , 2071-2079
- https://doi.org/10.1080/15257779408013208
Abstract
Novel types of bicyclonucleosides (3, 9) bearing a 3′,5′-epoxyimino (or iminoepoxy) bridge have been prepared using intramolecular Mitsunobu reactions. Contrarily to close analogs, also of the β-D-threo configuration but oxidizable to nitrones (2, 2′) which were found active against HIV, the new compounds exhibited no anti-HIV activity.Keywords
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