T‐Cell large granular lymphocytic leukemia following orthotopic liver transplantation
- 11 July 1995
- journal article
- case report
- Published by Wiley in American Journal of Hematology
- Vol. 49 (3) , 216-220
- https://doi.org/10.1002/ajh.2830490307
Abstract
Aggressive T‐cell neoplasms are an infrequent complication of allogeneic organ and bone marrow transplantation. To date, chronic T‐cell lymphoproliferative malignancies have not been described. The present case documents the occurrence of a T‐cell large granular lymphocytic leukemia (T‐LGL) in a patient following orthotopic liver transplantation. Genotype studies showed a clonal T‐cell receptor α‐chain gene rearrangement. A unique feature was the detection of a specific chromosomal deletion at 1p32 involving the tal‐1 gene, an abnormality previously described only in aggressive T‐cell neoplasms.Keywords
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