USE OF A PHYSIOLOGICAL COMPARTMENTAL MODEL FOR THE RAT TO DESCRIBE THE PHARMACOKINETICS OF SEVERAL CHLORINATED BIPHENYLS IN THE MOUSE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 8  (6) , 397-403
Abstract
Feasibility of extrapolating pharmacokinetics of some clorinated biphenyl congeners (PCB) from 1 animal species to another was investigated. The fate of 4 differently chlorinated biphenyls previously studied in the rat was determined in the mouse. Experimental tissue level, metabolism and excretion data were used to evaluate results predicted for each PCB after a physiological compartmental model for the rat was scaled to the mouse. Pharmacokinetic parameter values were obtained for further evaluations from data in the mouse, and to determine whether the congener-dependent relationships previously observed in the rat were present in the mouse. Pharmacokinetics were predicted by scaled model, and results obtained when model parameters were derived from mouse data were equally descriptive of experimental tissue distribution and excretion kinetics of PCB studied. Congener-dependent relationships among PCB model parameters for the mouse were more varied than for rat. Accuracy of pharmacokinetic model predictions extrapolated from rat to mouse was primarily a function of their similar congener-dependent rates of PCB metabolism.