Distribution of the saa Gene in Strains of Shiga Toxin-Producing Escherichia coli of Human and Bovine Origins

1 April 2003

journal article
Published by American Society for Microbiology in Journal of Clinical Microbiology

Vol. 41 (4) , 1775-8
https://doi.org/10.1128/jcm.41.4.1775-1778.2003

Abstract

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin ( saa ) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa -positive strains were detected more frequently ( P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association ( P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

Keywords

This publication has 17 references indexed in Scilit:

Verocytotoxin‐producing Escherichia coli (VTEC) other than serogroup 0157 from Scottish cattle
Veterinary Record, 2002
Direct Detection and Characterization of Shiga Toxigenic Escherichia coli by Multiplex PCR for stx ₁ , stx ₂ , eae , ehxA , and saa
Journal of Clinical Microbiology, 2002
Characterization of Saa, a Novel Autoagglutinating Adhesin Produced by Locus of Enterocyte Effacement-Negative Shiga-Toxigenic Escherichia coli Strains That Are Virulent for Humans
Infection and Immunity, 2001
Typing of Intimin Genes in Human and Animal Enterohemorrhagic and EnteropathogenicEscherichia coli: Characterization of a New Intimin Variant
Infection and Immunity, 2000
Non‐O157:H7 Pathogenic Shiga Toxin–ProducingEscherichia coli:Phenotypic and Genetic Profiling of Virulence Traits and Evidence for Clonality
The Journal of Infectious Diseases, 1999
Vero cytotoxin-producingEscherichia coli, particularly serogroup O157, associated with human infections in England and Wales: 1992–4
Epidemiology and Infection, 1996
Properties of Vero Cytotoxin-Producing Escherichia coli of Human Origin of O Serogroups Other than O157
The Journal of Infectious Diseases, 1992
Non-radioactively labelled polynucleotide and oligonucleotide DNA probes, for selectively detecting Escherichia coli strains producing Vero cytotoxins VT1, VT2 and VT2 variant
Molecular and Cellular Probes, 1991
Haemolytic uraemic syndromes in the British Isles, 1985-8: association with verocytotoxin producing Escherichia coli. Part 2: Microbiological aspects.
Archives of Disease in Childhood, 1990
Cloning and nucleotide sequencing of Vero toxin 2 variant genes from Escherichia coli O91 : H21 isolated from a patient with the hemolytic uremic syndrome
Microbial Pathogenesis, 1990