Product inhibition studies on bovine liver carbamoyl phosphate synthetase
- 1 September 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 141 (3) , 817-824
- https://doi.org/10.1042/bj1410817
Abstract
A study of the product-inhibition patterns of carbamoyl phosphate synthetase from bovine liver is reported. Inhibition by adenosine, AMP and inorganic ions is also reported. The results are in agreement with the previously proposed model in which the order of substrate binding is ATPMg, followed by HCO3−, ATPMg and NH4+. The order of product release on the basis of the reported results is carbamoyl phosphate, followed by ADPMg, ADPMg and inorganic phosphate.Keywords
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