A Direct and Sensitive Method for the Determination of Salicylamide in Microplasma Samples by High-Performance Liquid Chromatography Using Fluorescence Detection
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 14 (8) , 577-582
- https://doi.org/10.1080/00032718108055471
Abstract
A quantitative analysis of salicylamide in microplasma volumes by high-performance 1iquid chromatography using fluorescence detection is reported. The procedure is extremely simple and very rapid, involving the direct introduction of the plasma sample on the HPLC column. The assay procedure is linear over the concentration range studied, 0–100 ng/ml with correlation coefficient for the linear regression, r = 0.998. This assay procedure enables the detection of salicylamide as low as 5.0 ng/ml in plasma, using sample volume of 100 μl.This publication has 3 references indexed in Scilit:
- Fluorescence of boron complexes. VII. Fluorometric determination of salicylamide.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978
- Spectrophotofluorometric Determination of Salicylamide in Blood Serum and UrineJournal of Pharmaceutical Sciences, 1971
- Intestinal Drug Absorption and Metabolism I: Comparison of Methods and Models to Study Physiological Factors of In Vitro and In Vivo Intestinal AbsorptionJournal of Pharmaceutical Sciences, 1970