The development of obesity in preweanling obob mice

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Abstract
The body compositions of obob and lean (ob+ and ++) mice at 10, 12, 17 and 28 days of age were investigated using a cold stress test to identify the 2 groups. At each of these ages the obob mice contained significantly more fat than the lean. At 10 days 20% more fat was present and by 17 days the increase was 72%. The obob mice at 28 days contained nearly 3 times as much fat as the lean. Carcass energy was significantly higher in obob mice at all ages investigated. Other changes in body composition found in the 28 days obob mice, i.e., a reduction in total carcass N and water content, were already established in the 17 day old mice but differences at 10 and 12 days were not apparent. The livers of obob mice were significantly heavier than those from lean control mice at 28 days but no differences were detected at the earlier ages. The results were discussed with reference to the early origin of obesity in obob mice.