Synthesis of lipopeptides using hydrazone chemical ligation
- 1 September 1998
- journal article
- Published by Wiley in Chemical Biology & Drug Design
- Vol. 52 (3) , 180-184
- https://doi.org/10.1111/j.1399-3011.1998.tb01474.x
Abstract
In this paper we report that a hydrazinopeptide synthesized using solid‐phase N‐electrophilic amination with N‐Boc‐3‐(4‐cyanophenyl)oxaziridine reacted with a lipophilic peptide aldehyde to give the corresponding hydrazone plus an unexpected 1,3,4‐oxadiazolidinopeptide containing two peptide aldehyde units. This methodology allows the synthesis of large lipopeptides.Keywords
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