Laboratory Evaluation of Tick Repellents

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Abstract
The repellent effect of 539 chemicals was evaluated against the argasid tick Ornithodorus tholozani Labou. & Megn. A method for evaluating tick repellents on guinea pigs is described. Pyrethrum was outstanding and far superior to all the other chemicals tested in protecting from tick bites. Its effect was probably due mostly to a strong irritant effect on the ticks. It also had a strong delayed toxic effect on the ticks. Of the other chemicals tested, the following were significantly superior to a tick repellent (dibutyl butanephosphonate) which was used as a standard: N-alkyl (C12-C14)cyclohexylamine, 2-dicyclohexylaminoethanol, o-vanillin and capric acid. Twelve other chemicals were equal to the standard.

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