Role of Detergent Complexes in Experimental Gastric and Duodenal Ulcers.

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Abstract
Dogs injd. with histamine by the method of Code and Wangensteen develop gastric hypersecretion, "peptic" ulcers, and usually expire within 2 weeks, but if fed 1.8 g. of Mucosulf (a mucin-alkyl sulfate complex in capsules) in 2 daily doses of 900 mg. each, they survive for over 200 days. A significant reduction of gastric juice output due to detergent-complex therapy occurred with increases in relative viscosity, total available mucin, and mucin concn. The total available lysozyme decreased without change in lysozyme concn. There is a significant diminution of total pepsin and pepsin concns., but only a decrease in total available gastric acidity with no significant change in acid concn. (pH). Apparently, it is the pepsin rather than the acidity which plays the primary role in ulcer formation.

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