Hypoxic-ischaemic injury of the neonatal brain

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Abstract
Despite advances in obstetric and neonatal care, hypoxia-ischaemia remains as probably the commonest cause of severe disabling brain injury which occurs in the perinatal period. Although for the population as a whole, congenital brain abnormality and early fetal events are the most frequent antecedent of permanent neurodevelopmental disability, perinatal brain injury is an important and potentially preventable cause of severe and permanent handicap in both developed and developing countries.