Effect of Lubricants on Tensile Strengths of Tablets
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 10 (2) , 259-273
- https://doi.org/10.3109/03639048409064649
Abstract
The effect of concentration of lubricant on the axial and radial tensile strengths of tablets was determined for four directly compressible pharmaceutical materials: anhydrous lactose, aspirin, microcrystalline cellulose, and dibasic calcium phosphate dihydrate. The lubricants investigated were: hydrogenated vegetable oil, magnesium stearate, polyethylene glycol 4000, stearic acid, and talc. For plastic materials the tensile strengths were reduced as the concentration of the lubricant was increased. For brittle material the tensile strength was not changed significantly as the concentration of lubricant was increased.Keywords
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