Phosphorylation of Alcohols and Phosphates by Oxidation-Reduction Condensation
- 1 January 1971
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 44 (1) , 196-199
- https://doi.org/10.1246/bcsj.44.196
Abstract
Phosphorylation of alcohols and phosphates forming mixed esters of phosphoric acid and pyrophosphate by the oxidation-reduction condensation with triphenylphosphine and 2,2′-dipyridyl disulfide has been investigated. n-Butyl p-nitrophenyl phosphate was obtained in 80% yield when p-nitrophenyl dihydrogen phosphate was treated with one equiv. each of triphenylphosphine and 2,2′-dipyridyl disulfide in the presence of three equiv. of anhydrous n-butyl alcohol at room temperature. It was found that P1,P2-bis(p-nitrophenyl)pyrophosphate was obtained in 91% yield when p-nitrophenyl dihydrogen phosphate was treated with 1.5 equiv. each of triphenylphosphine and 2,2′-dipyridyl disulfide.Keywords
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