Effect of Total Gastrectomy on Acid Proteolytic Zymogens in Serum and Urine

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Abstract
Proteolytic pH-activity curve and agar gel electrophoretic pattern of acid proteolytic zymogens in serum and urine were studied in totally gastrectomized patients. In serum total gastrectomy reduced proteolytic activity markedly, but no appreciable changes were detected by electrophoretic analysis. In urine in addition to the marked reduction of proteolytic activity, changes were found in electrophoretic pattern after total gastrectomy. Pepsinogen fraction Pg 3 tended to persist, while Pg 5 disappeared with the lapse of time after total gastrectomy. An unusual appearance of fraction Pg 7 in urine was also observed on the occasion of postoperative transient albuminuria. Their origins and related clinical problems were discussed.