Crystal structure of a four-stranded intercalated DNA: d(C4)
- 1 November 1994
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 33 (46) , 13540-13546
- https://doi.org/10.1021/bi00250a005
Abstract
The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.Keywords
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