Role of Extracellular Ionized Calcium in the In Vitro Assessment of GPIIb/IIIa Receptor Antagonists
Open Access
- 1 January 2000
- journal article
- Published by Springer Nature in Journal of Thrombosis and Thrombolysis
- Vol. 9 (1) , 23-28
- https://doi.org/10.1023/a:1018679708251
Abstract
Several preclinical studies have found a poor correlation between the ex vivo platelet inhibitory potency and the in vivo antithrombotic efficacy of GPIIb/IIIa receptor antagonists. The present study...Keywords
This publication has 32 references indexed in Scilit:
- Effect of Ca 2+ on GP IIb-IIIa Interactions With IntegrilinCirculation, 1997
- Ligand Binding to Integrin αIIbβ3 Is Dependent on a MIDAS-like Domain in the β3 SubunitPublished by Elsevier ,1996
- An Allosteric Ca2+ Binding Site on the β3-Integrins That Regulates the Dissociation Rate for RGD LigandsPublished by Elsevier ,1996
- Calcium, calmodulin and protein kinase C dependence of platelet shape changeThrombosis Research, 1996
- Platelet Glycoprotein IIb/IIIa Receptors in Cardiovascular MedicineNew England Journal of Medicine, 1995
- Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)Cell, 1995
- Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand bindingCell, 1994
- Chimeric 7E3 prevents carotid artery thrombosis in cynomolgus monkeys.Stroke, 1994
- A β 3 Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent ConformationScience, 1990
- Organization of the gene for platelet glycoprotein IIbBiochemistry, 1990