Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances

1 April 2008

journal article
review article
Published by American Society for Microbiology in Clinical Microbiology Reviews

Vol. 21 (2) , 274-290
https://doi.org/10.1128/cmr.00045-07

Abstract

Though several antivirals have been developed and marketed to treat influenza virus infections, the development of antiviral agents with clinical activity against other respiratory viruses has been more problematic. Here we review the epidemiology of respiratory viral infections in immunocompetent and immunocompromised hosts, examine the evidence surrounding the currently available antivirals for respiratory viral infections other than influenza, highlight those that are in the pipeline, and discuss the hurdles for development of such agents.

Keywords

This publication has 234 references indexed in Scilit:

Role of respiratory syncytial virus in acute otitis media: Implications for vaccine development
Vaccine, 2007
Risk factors for severe RSV-induced lower respiratory tract infection over four consecutive epidemics
European Journal of Pediatrics, 2007
Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines
Biochemical and Biophysical Research Communications, 2004
HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus
Biochemical and Biophysical Research Communications, 2004
Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
Bone Marrow Transplantation, 2003
Respiratory syncytial virus–enriched globulin for the prevention of acute otitis media in high-risk children
The Journal of Pediatrics, 1996
Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection
The Journal of Pediatrics, 1995
Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children
The Journal of Pediatrics, 1992
An Outbreak of Respiratory Syncytial Virus in a Bone Marrow Transplant Center
The Journal of Infectious Diseases, 1992
Prevention of Natural Colds by Contact Prophylaxis with Intranasal Alpha₂-Interferon
New England Journal of Medicine, 1986