Regulation of hepatic carnitine palmitoyltransferase activity during the foetal‐neonatal transition
- 13 December 1982
- journal article
- Published by Wiley in FEBS Letters
- Vol. 150 (1) , 177-180
- https://doi.org/10.1016/0014-5793(82)81329-x
Abstract
Overt carnitine palmitoyl transferase (CPT1) activity was measured in liver mitochondria from foetal rats (21 days gestation) and from neonatal rats (1 day post-partum). Birth was accompanied by a 6-fold increase in CPT1 activity, a 14-fold decrease in sensitivity to inhibition by malonyl CoA and an increase in the n H and the S 0.5 from palmitoyl CoA. The activity of latent enzyme (CPT2) was unaffected at birth.Keywords
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