Moderate alcohol consumption in pregnancy and subsequent left-handedness. A follow-up study

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Abstract
Alcohol in high doses is neurotoxic to the developing brain but it is not yet settled whether small doses give rise to more subtle effects. The aim of the study was to establish whether a moderate intake of alcohol in pregnancy would increase the frequency of left-handedness in the offspring. Such an association could indicate a possible subtle prenatal neurotoxic effect. This was a follow-up study of a group of pregnant women who took part in a community trial in 1984 to 1987. Data on alcohol consumption were reported by consecutively sampled pregnant women in the 36th week of gestation. Hand preference for their offspring was reported by the mothers in a self-administered questionnaire when their children were 5 to 9 years old. Ninety-one percent participated in the follow-up study. The study showed that 9.1% of the children were left-handed, with a higher prevalence among boys (11.8%). Results showed a slightly higher frequency of being left-handed among children exposed to alcohol in fetal life, but the findings were not statistically significant at a 0.05 level.