Influence of Methodology on Electroencephalographic Sleep and Arousal: Studies with Reserpine and Etryptamine in Rabbits

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Abstract
In studies with reserpine and with etryptamine, quite opposite electroencephalographic effects were obtained when either of these two drugs was administered to rabbits prior to surgical preparation for EEG recording as opposed to the drug being given after the rabbits had been fully prepared for EEG recording. With the one method, EEG rhythms indicative of sleep were obtained, while with the other method, EEG rhythms indicative of central nervous system stimulation were obtained, although with both methods, the amount of drug, duration of drug in animal, and type of acute preparation were identical for both sets of findings. The presurgical injection procedure produced EEG results more in accordance with behavioral and biochemical findings, even though the conventional procedure is to administer the experimental drug after the animal has been prepared for EEG recording.