‘Double asymmetric induction’ as a novel tool for high stereocontrol in Baylis–Hillman reaction
- 30 September 2004
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 22,p. 2580-2581
- https://doi.org/10.1039/b411548a
Abstract
The strategy of double asymmetric induction was utilized in Baylis–Hillman reaction for the first time by the coupling of chiral aldehydes with chiral acrylate (1,2:5,6-di-O-isopropylidene-α-D-glucofuranose-3-acrylate) to obtain corresponding adducts with high syn diastereoselectivities (de >90%) in moderate to good yields.Keywords
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