Hematoencephalic Exchange as a Function of Age

Abstract
The relation between the changes in glutamic acid, glutamine, pyruvic acid, a-keto-glutaric acid, water and total N in the developing brain of the rat and the development of behavioral patterns are discussed. Hematoencephalic exchange of glutamic acid is relatively fast in the new-born rat as shown by increases in glutamine acid in brain when the blood level of this amino acid is raised, in the adult animal under similar circumstances the exchange cannot be detected by the methods used in this study.