Accelerated Development of Salivary Glands of Early Postnatal Rats Following Isoproterenol.

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Abstract
Chronic administration of the sympathetic amine isoproterenol to early postnatal rats (1-4 days old) for selected periods of time results in marked increases in the size of the submaxillary and parotid glands, and to a less extent, in the size of the heart. The sublingual salivary gland is unaffected. A clear effect on differentiation of the parotid and submaxillary glands was observed with the isoproterenol treatment (1.5 mg twice daily for varying time intervals). The effect is most marked in parotid, where acini develop much earlier than in the litter-mate controls and striated ducts become more abundant The effects of isoproterenol on differentiation are separable from the influence of the drug on cell size. An effect of the sympathetic drug on development is thus indicated.

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