Endocytosis and formation of macrophage polykarya: An ultrastructural study

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Abstract
Mononuclear phagocytes [mouse] in foreign body granulomas became entrapped by the lamellipodia or entered the intracytoplasmic membranous labyrinth of macrophage polykarya. Evidence of membrane fusion was found in such instances and the internalization of the mononuclear phagocyte was allied to the motility of the syncytium. Other reports emphasizing the role of endocytosis in the formation of macrophage polykarya were supported. The net effect of such a mechanism was growth of the syncytium.