Stereoselektive Synthese von optisch aktivem Vincamin
- 23 April 1975
- journal article
- abstracts
- Published by Wiley in Helvetica Chimica Acta
- Vol. 58 (4) , 1131-1145
- https://doi.org/10.1002/hlca.19750580416
Abstract
Vincamine (13) was prepared from the aldehyde 8 in 5 steps using methyl dimethyl‐phosphono‐methoxy‐acetate as a synthon for the pyruvic ester residue. A method to convert apovincamine (12) into vincamine (13) has hen worked out. Optically active 8 was synthesized from ethyl‐malonaldehydic acid ethyl ester in 9 steps including optical revolution of the acid intermediate 3 by means of salt formation with L‐(+)‐pseudoephedrine. The two diastereomeric salts were distinguishable by NMR. in carbontetrachloride.Keywords
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