ACQUIRED RESISTANCE TO WATER INTOXICATION

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Abstract
When water was given orally in increasing but non-toxic doses for 5 days, resistance to water intoxication was increased well above normal in rats. This acquired resistance was due partly to adaptation to the effects of passage of a stomach tube. Adaptation to damaging doses of intraperitoneal glucose solns. provided slight if any protection against water intoxication. The resistance to water intoxication in adapted animals was not dependent entirely upon the characteristically increased rate of diuresis. When diuresis was inhibited by vasopressin, adapted animals had less marked toxic symptoms at a given water load than normal ones. It was not clearly established that there was an increased rate of diuresis in adapted animals given non-toxic doses of water. Removal of the adrenal glands largely abolished the protective effects of adaptation to excess of water, but the conclusion is not justified that the adaptation was mediated through the adrenals.

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