Variability of Standard Curves in Radioimmunoassay of Plasma Digoxin

Abstract
Evaluation of commercial kits (3H and 125I digoxin) for the radioimmunoassay of digoxin showed that different normal plasma samples yielded significantly different standard assay curves. Such differences accounted for errors of from 0.6 to 1 ng under certain conditions. The usual internal assay controls do not correct for these conditions. Because such changes may represent the differences between toxic and nontoxic digoxin concentrations, further study of the commercial test procedures appears to be indicated.

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