Prenatal Exposure to Phenobarbital Permanently Decreases Testosterone and Causes Reproductive Dysfunction
- 7 May 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4546) , 640-642
- https://doi.org/10.1126/science.7200262
Abstract
Exposure of rats to phenobarbital during late prenatal development decreased the concentration of testosterone in plasma and the brain during the late fetal, early postnatal, pubertal, and adult periods, By decreasing the production of testosterone in the brain during the period of sexual differentiation, phenobarbital may lead to sexual dysfunction in later life.This publication has 17 references indexed in Scilit:
- Inflammation in Uremic Patients: What Is the Link?Kidney and Blood Pressure Research, 2003
- Phenobarbital Exposure in Utero: Alterations in Female Reproductive Function in RatsScience, 1980
- Brain and plasma levels of testosterone, dihydrotestosterone and estradiol in the one-day-old ratLife Sciences, 1979
- Sex hormone metabolism in the brain: Influence of central acting drugs on 5.ALPHA.-reduction in rat diencephalon.Endocrinologia Japonica, 1979
- Effects of Neonatal Androgenization on Serum Gonadotropin Levels of Prepubertal and Adult Male and Female RatsNeuroendocrinology, 1978
- Effects of phenobarbital given to pregnant mice on behavior of mature offspringDevelopmental Psychobiology, 1975
- Lowered Ovarian Conversion of14C-Pregnenolone to Progesterone and other Metabolites during Phenobarbital (PB) Block of PMS-Induced Ovulation in Immature Rats: Inhibition of 3β-Hydroxysteroid Dehydrogenation*Endocrinology, 1973
- Antigenic complexes of steroid hormones formed by coupling to protein through position 7: Preparation from Δ4 -3-oxosteroids and characterization of antibodies to testosterone and androstenedioneSteroids, 1972
- Hormones and Sexual BehaviorScience, 1964
- The Distribution and Excretion of Phenobarbital1Journal of Clinical Investigation, 1957