PSYCHOLOGIC disturbances may be of etiologic significance in certain endocrine disorders as Hoskins (1) has recently emphasized in discussing thyrotoxicosis. This is a paradigm of psychosomatic disease. The psychosomatic approach must, however, include conditions which are better described as somatopsychic, in that the phyical disturbance is definitely primary. Under such a heading fall the endocrine deficiency states such as myxedema, with its classic picture of retarded mental processes and the less frequently occurring but none the less definite psychosis. Close inspection reveals that the psychologic picture in nryxedema is not so classically clear as to be pathognomonic and that very little systematic psychiatric assessment has been recorded. Only recently have intellectual functions in myxedema been investigted by quantitative, protective tests (2). Addison's disease belongs to the same category as myxedema, from both the endocrinologic and psychologic point of view, but does not always exhibit as striking a set of mental changes. Interest in the mental state of patients with adrenal insufficiency has grown as the result of two developments in the past decade. These are, 1) the emphasis placed by the psychosomatic approach on the importance of psychologic aberrations in a variety of diseases and 2) the recent studies indicating that there is hypofunction of the adrenal in schizophrenia. Thus, observations concerning this gland are both critical and topical.